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Bioavailability of Drugs:Principles and Problems
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Book : Bioavailability of Drugs:Principles and Problems
Language : English Library : Social Phsician Publish Place : Geneva ISBN : 92 4 120536 9 Volume : 536 Publish Date : 00 1974 Publisher : World Health Organization WHO Book Type : Report Book Number : 3467 |
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INDEX
CONTENTS
1. Introduction ......................................................
2. General considerations..........................................
3. Biopharmaceutical and other factors influencing the plasma concentration of drugs and their excretion in urine................................
3.1 Biopharmaceutical factors influencing bioavailability...............
3.2 Other factors influencing drug plasma concentration and excretion in urine......................................................
4. Methods of testing................................................
4.1 General considerations..........................................
4.2 Preliminary procedures...... ...............
4.3 Experimental procedure........................................
5. Correlation of bioavailability data in man with data from other sources
5.1 Therapeutic efficacy and adverse effects..........................
5.2 Animal models..........................
5.3 In vitro tests..................................................
6. Specifications for bioavailability.....................................
6.1 Bioavailability reference formulations..................
6.2 Acceptable differences in bioavailability of different formulations of the same drug................................................
7. Priorities........................
8. Personnel requirements...........
9. Research needs..................
10. Conclusions and recommendations
